Table of Contents
Controlled Drug Delivery
Introduction to controlled drug delivery systems
Physical issues in controlled drug delivery systems
Advantages of controlled delivery systems
History of controlled delivery
Microencapsulation
Physical encapsulation: The Wurster process
Coacervation: encapsulation of liquids
Implants for drug delivery
Norplant: an example of an implant
Implantable pumps
Transdermal drug delivery
Methods of transdermal drug delivery
The monolithic design
The reservoir design
Site-directed drug delivery
Formulations
Liposomes
Liposome targeting
Advantages of liposome delivery
Colloidal drug delivery
Nanoparticles
Properties of nanoparticles
Physical aspects of nanoparticles
Polymeric drug delivery
Biodegradable polymers
Applications of polymers
Matrix device
Interfacial polymerization
Coacervation
Spray drying
Immunochemical targeting
The role of phagocytosis in colloidal drug delivery
Avoiding phagocytosis by enthalpic stabilization
Using phagocytosis and endocytosis for intracellular drug delivery
Intracellular targeting
Surfactants
Properties of surfactants
Complementary role of surfactants
Membrane transport by surfactants
Solubility enhancement by surfactants
Physical aspects of surfactants and micelles
Example: use of surface tension measurement to determine the CMC
Limitations of surfactants
Delivery by red blood cells
Properties of red blood cells
Viral Vectors
Physical Chemistry of Drug Delivery
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