Aggregation
Kinetic stability is a measure of how rapidly a protein unfolds.
It is a particularly important consideration for proteins that
unfold very slowly or denature irreversibly. A protein can
denature irreversibly if the unfolded protein rapidly undergoes
some permanent change such as aggregation (egg white) or
proteolytic degradation (subtilisin). This is indicated in the
We are concerned here with irreversible aggregation associated
with changes in protein structure.