The folding of apomyoglobin

Experimental results indicate that formation of secondary

preceeds tertiary structure by nearly three orders of magnitude in

time. The energy surface of apomyoglobin appears to have a sizable

energy trap that leads

to formation of the

AGH core that remains

throughout the rest of the

folding pathway, perhaps

serving as a template.

U = unfolded

E = early intermediate

I = intermediate

N = native (apoMb)

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